| Colorado Springs Switchbacks | 2:0 | Miami FC | American USL Championship | 09:00 |
| Spokane Velocity | 3:0 | Charlotte Independence | American USL League One | 09:00 |
| Belgrano | — | Rosario Central | Argentinian Primera Division | 06:30 |
| Sarmiento | — | Argentinos Juniors | Argentinian Primera Division | 06:30 |
| Botafogo | — | Vitória | Brazilian Serie A | 06:30 |
| Chapecoense | 0:4 | Flamengo | Brazilian Serie A | 08:30 |
| Corinthians | — | Remo | Brazilian Serie A | 06:30 |
| Internacional | 1:2 | Cruzeiro | Brazilian Serie A | 08:30 |
| São Paulo | 1:2 | Athletico Paranaense | Brazilian Serie A | 08:30 |
| Charlotte FC | 2:2 | Atlanta United | American Major League Soccer | 08:15 |
| Austin FC | 3:1 | Seattle Sounders | American Major League Soccer | 09:30 |
| Nashville SC | 1:0 | CF Montréal | American Major League Soccer | 08:30 |
| Sporting Kansas City | 2:1 | Minnesota United | American Major League Soccer | 08:30 |
| Houston Dynamo | 1:1 | DC United | American Major League Soccer | 08:30 |
| Colorado Rapids | 1:0 | San Diego FC | American Major League Soccer | 09:30 |
| Los Angeles FC | 3:1 | Real Salt Lake | American Major League Soccer | 10:30 |
| LA Galaxy | 1:3 | St. Louis City SC | American Major League Soccer | 10:30 |
| San Jose Earthquakes | 0:4 | Orlando City | American Major League Soccer | 10:30 |
| Portland Timbers | 2:2 | FC Dallas | American Major League Soccer | 10:30 |
| Whitecaps FC 2 | 0:4 | Austin FC II | MLS Next Pro | 09:00 |
